Comparison between monoammonium glycyrrhizinate and diammonium glycyrrhizinate

Both are active ingredients extracted from licorice. They differ in chemical structure, which leads to differences in their pharmacological effects and clinical applications.

These two are different drugs. Their main difference lies in their different actions and effects in the body. Diammonium glycyrrhizinate has stronger anti-inflammatory, anti-allergic and immunomodulatory effects in the body, while monoammonium glycyrrhizinate is relatively weaker.

1.Comparison of chemical structures

The chemical structure of monoammonium glycyrrhizinate is that one hydroxyl group in glycyrrhizic acid is replaced by an ammonium group

The chemical structure of diammonium glycyrrhizinate is that two hydroxyl groups in glycyrrhizic acid are replaced by ammonium groups

This is the main difference in chemical structure between the two.

2.Comparison of ingredient differences

monoammonium glycyrrhizinate is a first-generation glycyrrhizic acid preparation, mainly containing α-isomer glycyrrhizic acid. And diammonium glycyrrhizinate is a third-generation glycyrrhizic acid preparation, which contains a mixed preparation of α-body and β-body, which means that its chemical composition is different from monoammonium glycyrrhizinate.

3. Comparison of pharmacological effects

Monoammonium glycyrrhizinate, an active ingredient extracted from licorice, has antibacterial, anti-inflammatory, detoxifying, anti-tumor, anti-toxic and infection-like effects and adrenocortical hormone-like effects.

Anti-inflammatory and anti-allergic: It has adrenocortical hormone-like effects without its side effects. It can be anti-inflammatory and anti-allergic. It can reduce immunopathological reactions by acting on hormone receptors and other methods. For example, it is used in the treatment of bronchiolitis in infants and young children. The symptom improvement of the monoammonium glycyrrhizinate treatment group was significantly better than that of the control group.

Regulating immunity: It can regulate substance metabolism, regulate the excitability of cholinergic nerves, and regulate immune function. When treating viral hepatitis, it can reduce interleukin-6 and tumor necrosis factor in the serum and peripheral mononuclear cells of patients with chronic hepatitis. Increase the concentration of serum hydrocortisone in patients with hepatitis and promote the recovery of liver function.

Other effects: It has anti-viral, protective membrane structure, anti-ulcer and anti-spasmodic effects. It has therapeutic effects on various diseases such as chronic persistent hepatitis, chronic active hepatitis, liver poisoning, early cirrhosis, etc. It also has therapeutic effects on digestive tract infections, hepatitis B, It also has certain curative effects on oral ulcers, gastric ulcers, etc. It also has strong detoxification effects on various toxins such as diphtheria toxin, tetrodotoxin, tetanus toxin and snake venom.

Diammonium glycyrrhizinate, an extract of the active ingredient of the traditional Chinese medicine licorice, has certain anti-inflammatory effects, protects liver cells, and improves liver function.

Anti-inflammatory and liver-protecting: It also has adrenocortical hormone-like effects without its side effects. It has obvious anti-inflammatory effects and is suitable for the treatment of acute and chronic viral hepatitis. Especially for chronic active hepatitis B and chronic active hepatitis C, it can be significantly improved. Clinical symptoms and liver function, its efficacy is better than monoammonium glycyrrhizinate and adrenocortical hormone, it can reduce the inflammatory response of liver tissue and protect the liver cell membrane.

Regulation of immunity: It also plays a certain role in regulating immunity. It can participate in the body's immune regulation process and help improve immune abnormalities in liver diseases.

4.Comparison of clinical applications: Both monoammonium glycyrrhizinate and diammonium glycyrrhizinate are used to treat hepatobiliary diseases, but as products of different generations, diammonium glycyrrhizinate may have been optimized in formula to improve efficacy or reduce side effects.

Monoammonium glycyrrhizinate: Liver disease: Mainly used in the treatment of chronic persistent hepatitis, chronic active hepatitis, liver poisoning, early cirrhosis and other liver diseases. It can improve the patient's liver function, reduce hepatosplenomegaly, reduce enzymes quickly, and Jaundice is significant and has anti-hepatic fibrosis effects.

Other diseases: In addition to liver diseases, it can also be used to treat respiratory diseases such as tracheitis, bronchitis, cough, asthma, etc. It can also be used to treat bronchiolitis in infants and young children to reduce complications, sequelae, and restore the function of damaged organs. It has good effects in other aspects, such as the treatment of organophosphorus pesticide poisoning.

Diammonium glycyrrhizinate

Liver disease: It is suitable for the treatment of acute and chronic viral hepatitis with elevated alanine aminotransferase (ALT). It has a good effect on improving liver function and reducing transaminase. It is also suitable for the treatment of chronic active hepatitis B and C. The efficacy is better.

Anti-allergy: Compound glycyrrhizin (the main ingredient contains glycyrrhizin, etc.) can be used to treat allergic diseases such as eczema, dermatitis, urticaria, etc. Diammonium glycyrrhizinate itself also has certain anti-inflammatory and anti-allergic effects, although it is different from the compound glycyrrhizin. Glycyrrhizin is not exactly the same, but they have similarities in pharmacological mechanisms, and they are all related to the anti-inflammatory, immune-regulating and other functions of glycyrrhizic acid substances.

5. Comparison of efficacy and safety: Although both have anti-inflammatory and hepatocellular protective effects, diammonium glycyrrhizinate may be designed to focus more on improving treatment selectivity and reducing potential adverse reactions, which is consistent with its use as a more The characteristics of later generation products are consistent.